Director, Data Systems Engineering

  • Anywhere


Rarebase is an early-stage biotechnology public benefit corporation based in Palo Alto, California working to advance personalized medicine for the thousands of genetic diseases that have no effective treatments. We operate at the intersection of technology and biology, collaborating closely with patient communities to ensure that drug discovery and development is aligned with our shared goals – to bring effective treatments to the clinic as quickly and safely as possible.

Our Function™ drug and target discovery platform integrates cellular modeling of disease with functional genomics, high throughput screening, high content imaging and computational biology to identify molecules that address the underlying biology of genetic diseases. To support Function’s rapid growth, we are building a next-generation automated lab and are recruiting a San Francisco Bay Area-based scientific team to be intimately involved in its development.

Rarebase is backed by top-tier institutional investors, pharma and biotech angel investors, families personally affected by rare disease, and others that truly care about our mission to re-invent therapeutic development for genetic diseases. Our advisors are leaders in the biotech and genetic disease community.

The Opportunity

We’re looking for a Director of Data Systems Engineering to lead the development of a data pipeline and assist in the design, execution and scale-up of a biological data platform to identify therapies for rare diseases.

The ideal candidate will have experience with database design, data wrangling and curation and leading teams to deliver internal and external software products. Interest and skills to help integrate databases with machine learning and artificial intelligence algorithms is a requirement.

The individual in this role will work closely with the broader scientific team to build out the analysis pipeline that will support development of our work.

As an early member of Rarebase’s computational biology team, you will be joining a biotech startup that has long term stability but yet is very much in formation, providing many opportunities for significant growth and impact. You will also work alongside a multidisciplinary team and an outstanding group of scientists, computational scientists and AI experts focused on conducting inventive and innovative science that will lead to the discovery of novel medicines.

What you’ll do

Apply your expertise with data engineering and software design to build a versatile database and modeling platform

Oversee the standardization and automated acquisition of diverse data sources and develop integrated, query-based databases

Lead a team of software engineers to develop a user-friendly front-facing application for rare disease foundations and patients

Work with a team of AI experts and biologists to integrate data pipelines with predictive models.

Champion ideas for new approaches to rapidly integrate and learn from high-dimensional, diverse data

Collaborate closely with the broader computational team including artificial intelligence experts, computer vision / image specialists and data engineers, and the science team (neuroscientists, high-throughput biologists, clinical design experts)

Communicate data and scientific results to both internal and external audiences with a high degree of sophistication.

What you’ll bring

B.S., Masters or PhD in Computer Science, Electrical Engineering or related discipline

5+ years of experience of industry experience in database design and leading engineering teams

Track record of building internal data pipelines and external-facing tools

Ability to program in Python and quickly pick up new languages and tools

Experience working with Google Cloud, AWS, DataBricks

Implements best practices (version control, commenting, documentation, metadata tags)

Excellent communication and interpersonal skills with an ability to work both independently and in a team environment

A relentless drive and curiosity coupled with great resilience and adaptability

What we offer

An opportunity to work closely with a cutting-edge, interdisciplinary technology team and patient organizations on translational research

Premium health and dental insurance

Competitive salary and equity in a growing, well-funded startup

Generous vacation policy

Originally posted on Himalayas

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